Core equipment includes Liquid Chromatography-Tandem Mass Spec (triple quadrupole and Q-TOF ), Amino Acid Analyzer (Biochrom 50), HPLC- UV-Vis (Agilent 1050, 1100), and Gas Chromatography-Mass Spectrometry (Agilent 5971, 5973).Īctive Recharge: Yes Bioengineering/Orthopaedic Sugery MicroComputed Tomography Facilityįaculty Director: Edwin Stephan, Pr Dev Engrĭepartment: Center for Astrophysics & Space Sciencesĭescription: CASS Research and Engineering Services and Test Facilities: The CASS thermal/vacuum facility is a vacuum chamber (4 ft diameter x 7 ft long) with porting for cold gas/LN2 interface to custom thermal shrouds with heaters for thermal control in the -150C to +50C range.Enzyme assays of HPRT and APRT in RBC and fibroblasts, and methylcrotonyl-CoA carboxylase, pyruvate carboxylase and propionyl-CoA carboxylase in leukocytes and fibroblasts.Specialized testing for intracellular cystine determination, including diagnosis of cystinosis by leukocytes and fibroblasts, and cysteamine therapy monitoring.Metabolomic determinations including those classes of compounds, and purines and pyrimidines, short chain fatty acids, and some carbohydrates.The large range of procedures and tests conducted in-house by the laboratory is complemented and expanded by use of established outside reference laboratories when necessary, as coordinated by the laboratory.Īctive Recharge: Yes ACP Irradiation Servicesįaculty Director: Bruce Barshop, Professor Emeritus, Pediatricsĭescription: The Biochemical Genetics and Metabolomics Lab performs metabolic screening, organic acid, amino acid, and acylcarnitine analysis for researchers and patients at UC San Diego and non-UC San Diego medical institutions. The diagnostic laboratory is overseen by a veterinary pathologist, and staffed by experienced laboratory technicians. Prices for these services are determined on a cost recovery basis. Contact: Cheryl Yost, Nicole Gardner, Staff Res Assocs, (858) 534 4264ĭescription: The Animal Care Program Diagnostic Services Laboratory provides a broad spectrum of clinical pathology and morphologic pathology services for research support (e.g., safety/toxicology testing, individual animal model-related tests,p henotype analysis), as well as colony and individual animal health diagnostics and care. Pre-pulse Inhibition (SR-Lab San Diego Instruments): schizophrenia-like behaviors and sensory inhibitionĪctive Recharge: Yes ACP Caesarian Rederivation Servicesįaculty Director: Kent Osborn, Veterinary PathologistĪlt.Startle Response (SR-Lab San Diego Instruments): hearing ability.Tube Test: social dominance and aggressive tendencies.Tail Flick (Columbus Instruments): pain reflexes and/or analgesia.Hot Plate (Columbus Instruments): pain reflexes and/or analgesia.TreadScan (Clever Systems): forced walking gait analysis.Treadmill (Columbus Instruments): motor coordination.Rotarod (UGO Basile): motor function and coordination.Open Field (Accuscan): exploratory locomotor activity.Grip Strength (UGO Basile): forelimb grip strength.Foot Misplacement (Columbus Instruments).Balance Beam: motor coordination and balance.Motor Coordination/Strength and Locomotion:.CLAMS (environmental control of temperature and lighting, oxygen intake, carbon dioxide output, calorimetric assessment, activity, drinking, feeding, food access control) (Columbus Instruments).CLAMS (oxygen intake, carbon dioxide output, calorimetric assessment) (Columbus Instruments).Metabolic cages: basic (food/water uptake, urine output non-automated).Radial Arm Maze (San Diego Instruments): spatial learning.Passive Avoidance (San Diego Instruments).Morris Water Maze (ANY-maze San Diego Instruments): spatial learning.Conditioned Place Preference (San Diego Instruments).Barnes Maze (San Diego Instruments): spatial learning and memory.Active Avoidance (San Diego Instruments).DEXAscan: Body composition via measurement of bone mineral density and % fat.Non-invasive Blood Pressure (Columbus Instruments).
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